Human Antibodies

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Human Antibodies

BioLabs


The Human Antibody laboratory produces fully-human, full-length, antigen-specific antibodies for use in studying human immune responses. The lab has breakthroughs in antibody technology and hundreds of high affinity protective antibodies to influenza, anthrax lethal toxin, and various S. pneumonia polysaccharides.


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Overview

The Human Antibody laboratory produces fully-human, full-length, antigen-specific antibodies for use in studying human immune responses. The lab has breakthroughs in antibody technology and hundreds of high affinity protective antibodies to influenza, anthrax lethal toxin, and various S. pneumonia polysaccharides. Investigators are supported by helping quantify the antibody secreting cell responses after vaccination and by generating human monoclonal antibodies to be characterized. Pathogen-specific human monoclonal antibodies are also available for licensing agreements and other forms of commercial development.

The Human Antibody Facility Provides the Following Services:

  20 Antibodies from ASCs After Vaccination (Facility sorts)

  20 Antibodies from ASCs After Vaccination (Customer sorts)

  Cloning of Antibodies (mouse or human) Into Expression Vector

  Expression of Antibodies (human or humanized)

  4-plate transfection (50-500 micrograms of product)

  20-plate transfection (250-2500 micrograms of product)

  40-plate transfection (500-5000 micrograms of product)

  80-plate transfection (1-10 milligrams of product)

  Elisa (1-4 plates, customer supplies antigen)

  Hybridoma Sequencing

  Site-specific Mutagenesis or Reversion of Antibody or Germline

  Non-antibody Protein Express (in HEK293 or BL21)

Customize

Available Services
N/A 20 Antibodies from ASCs After Vaccination 20 Antibodies from ASCs after Vaccination Cloning Antibodies into Expression Vector Expression of Antibodies 4-plate Transfection, 50-500 micrograms of product 20-plate Transfection, 250-2500 micrograms of product 40-plate Transfection, 500-5000 micrograms of product 80-plate Transfection, 1-10 milligrams of product Elisa, 1-4 plates Hybridoma Sequencing Site-specific Mutagensis Site-specific Reversion

Site-specific Antibody Germline Hybridoma Sequencing Non Antibody Protein Express, in HEK293 or BL21

COLLECT:

Custom collections from a pool of thousands of healthy donors.

CHARACTERIZE:

Flowcytometry characterization of immune cells.

ISOLATE:

Research or GMP grade positive or negative cell selection procedures.

EXPAND:

Flask or automated expansion services.

FREEZE:

Controlled rate freezing using custom cryo-preservatives.

STORE:

Monitored LN2 vapor phase storage of products and samples.