Exposures to someone else’s blood can sometimes trigger an immune response in the recipient. About 5% of individuals when exposed to blood through a transfusion or through a pregnancy will develop antibodies to proteins on the surface of the donor’s red blood cells or platelets. If this occurs, the specificity of this antibody must be determined before another blood transfusion or pregnancy occurs.
Detection and identification of antibodies directed toward cell surface blood group systems is a critical step in providing safe biological products to patients. Screening tests are used for detection of antibodies that could lead to an immune response in the patient. If screens are positive, panels of cells are used to identify the specificity of the FAB region of the antibody. Depending on the frequency of the antigen in a normal population, samples from extremely rare red blood cells and antisera may be required. Additionally, laboratory methods to remove and isolate antigens and antibodies may be utilized. Our labs meet the stringent criteria required by the AABB to be designated as an accredited immunohematology reference laboratory. Blood group reagent lot release testing and certification can also be performed.
Custom collections from a pool of thousands of healthy donors.
Flowcytometry characterization of immune cells.
Research or GMP grade positive or negative cell selection procedures.
Flask or automated expansion services.
Controlled rate freezing using custom cryo-preservatives.
Monitored LN2 vapor phase storage of products and samples.
CFU Cultures & Assays Services
Infectious Disease Testing Services
Quantum Cell Culture
CliniMACS Cell Separation
Clinical Immunology Laboratory
Human Antibody Services