Platelet products are either manufactured from: apheresis collections, also known as single donor platelets (SDP), platelet apheresis or apheresis platelets; or whole blood derived platelet concentrates. Five units of whole blood derived platelet concentrates are pooled together to make a therapeutic platelet dose. All platelet products are tested for bacterial contamination using a culture system. HLA matched or cross matched platelets may be needed to treat patients with post-transfusion platelet refractoriness, when their platelet count does not adequately rise after a platelet transfusion due to HLA and/or platelet antibodies.
Platelet concentrates can be prepared from whole blood units or from apheresis devices. Whole blood-derived platelets are prepared by using low RPM centrifugation to separate the platelet-rich plasma (PRP) from the red blood cells. The PRP component is transferred to another bag and then exposed to high RPM centrifugation to create a platelet pellet in the bottom of the component bag. Using a small volume of plasma, the pellet is re-suspended and stored at room temperature for up to 5 days post collection. Each of these units contain approximately 5.5 X 1010 platelets. Platelet units include some WBC’s, 50 mL of plasma and a few RBC’s (Hct less than 0.005%). The PRP method of production is common in North America, but other counties us the Buffy Coat method to produce these products.Apheresis derived platelets are prepared using an automated process where blood is drawn from the donor into an apheresis instrument which separates the blood into its components, retains some of the platelets, and returns the remainder of the blood to the donor. This single donor platelet product contains about four to six times as many platelets as a unit of platelets obtained from whole blood. Units are available as <1.5 X 1011, 1.5-3.0 X 1011, or > 3.0 X 1011 platelets/unit. Each unit contains approximately 300 mL of plasma, a few WBCs (< 5 X 106) and trace amounts of RBCs.
Custom collections from a pool of thousands of healthy donors.
Flowcytometry characterization of immune cells.
Research or GMP grade positive or negative cell selection procedures.
Flask or automated expansion services.
Controlled rate freezing using custom cryo-preservatives.
Monitored LN2 vapor phase storage of products and samples.
Buffy Coat Products
Leukocyte Reduction System Products
Peripheral Blood Mononuclear Cell (PBMC) Products
Bone Marrow Products
Hematopoietic Stem Cell Products
Mesenchymal Stromal Cell Products
Red Blood Cell Products