Red Blood Cells (RBC) transport oxygen to tissues and deliver CO2 from the tissues to the lungs. These hemoglobin filled cells are 8-10 microns in size, have no nucleus, cytoplasmic structures or other organelles. The bi-concave disc shape provides the pliability needed to allow the cell to move through 3 micron capillary spaces. The RBC cell wall is a phospholipid bilayer containing many antigenic structures that make up blood types and groups.
Human Red Blood Cell samples and products are manufactured in a closed system by placing the whole blood units in a calibrated centrifuge or using apheresis technology. High RPM centrifugal force causes the heavier red blood cells to concentrate in the bottom of the collection system. After centrifugation, plasma is pushed from the RBC product to another bag integrally connected to the collection bag. From a whole blood collection, a portion of the Citrate-Phosphate-Dextrose (CPD ≈ 26.3 g/L tri-sodium citrate, 3.7 g/L citric acid, 2.22 g/L monobasic sodium phosphate, 25.5 g/L dextrose) anticoagulant in the collection bag remains in the RBC product. The hematocrit of the resulting unit is between 65-80%. Apheresis derived RBC’s contain Anticoagulant Citrate-Dextrose Solution, Solution A (ACD-A ≈ 26.3 g/L tri-sodium citrate, 3.7 g/L citric acid, 24.5 g/L dextrose). Depending on customer needs, products can be modified by filtration and addition of preservatives.
Custom collections from a pool of thousands of healthy donors.
Flowcytometry characterization of immune cells.
Research or GMP grade positive or negative cell selection procedures.
Flask or automated expansion services.
Controlled rate freezing using custom cryo-preservatives.
Monitored LN2 vapor phase storage of products and samples.
Buffy Coat Products
Leukocyte Reduction System Products
Peripheral Blood Mononuclear Cell (PBMC) Products
Bone Marrow Products
Hematopoietic Stem Cell Products
Mesenchymal Stromal Cell Products